Effects of fetal antiepileptic drug exposure: Outcomes at age 4.5years
نویسندگان
چکیده
منابع مشابه
Effects of fetal antiepileptic drug exposure: outcomes at age 4.5 years.
OBJECTIVE To examine outcomes at age 4.5 years and compare to earlier ages in children with fetal antiepileptic drug (AED) exposure. METHODS The NEAD Study is an ongoing prospective observational multicenter study, which enrolled pregnant women with epilepsy on AED monotherapy (1999-2004) to determine if differential long-term neurodevelopmental effects exist across 4 commonly used AEDs (carb...
متن کاملFetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study.
BACKGROUND Many women of childbearing potential take antiepileptic drugs, but the cognitive effects of fetal exposure are uncertain. We aimed to assess effects of commonly used antiepileptic drugs on cognitive outcomes in children up to 6 years of age. METHODS In this prospective, observational, assessor-masked, multicentre study, we enrolled pregnant women with epilepsy on antiepileptic drug...
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We previously reported that foetal valproate exposure impairs intelligence quotient. In this follow-up investigation, we examined dose-related effects of foetal antiepileptic drug exposure on verbal and non-verbal cognitive measures. This investigation is an ongoing prospective observational multi-centre study in the USA and UK, which has enrolled pregnant females with epilepsy on monotherapy f...
متن کاملAntiepileptic drug use during pregnancy: Perinatal outcomes
PURPOSE This study was undertaken to (1) measure the frequency of AED monotherapy or polytherapy during pregnancy and AED discontinuation prior to pregnancy in a cohort of women with treated epilepsy; and (2) describe the frequency of major congenital malformations according to maternal use of AED during pregnancy. METHODS A cohort of epileptic pregnant women was identified within the Quebec ...
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Active epilepsy with recurrent seizures is associated with a range of well-documented unfavourable consequences. Nevertheless, adverse metabolic effects of antiepileptic drug (AED) treatments have only recently received attention. Such effects may be subtle, insidious, take many years to become clinically apparent, and may have a negative impact on general health for many decades. Unfortunately...
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ژورنال
عنوان ژورنال: Yearbook of Neonatal and Perinatal Medicine
سال: 2012
ISSN: 8756-5005
DOI: 10.1016/j.ynpm.2012.06.079